Publications

103, 2017

DIS state – A new step towards the new ISO standard for the A-YES®

March 1st, 2017|Comments Off on DIS state – A new step towards the new ISO standard for the A-YES®

In 2015, an international interlaboratory study was carried out in the field of standardization with A-YES® , along with the establishment of an ISO standard. To validate the A-YES® for the determination of the LID (Lowest Ineffective Dilution) as well as the EEQ (Estradiol Equivalent Concentration), 14 laboratories participated by analyzing environmental samples and extracts. New_diagnostics GmbH supplied the participants with material, reagents and of course the yeast A. adeninivorans. Our partner company QuoData Gmbh analyzed the resulting data and constructed a detailed report. The results of the interlaboratory study were presented to [...]

2102, 2017

SETAC 2017

February 21st, 2017|Comments Off on SETAC 2017

When?  7th - 11th of May Where?  SQARE conference center, Brussels, Belgiumn Where exactly can you find us at SETAC? In cooperation with QuoData GmbH we will present two posters whithin track 6 "Environmental policy risk management and risk communication". Within session 6.02"Development and validation of standardised methods and their use in regulatory frameworks" you can find our poster about "ISO/CD 19040-2 Water quality - Determination of the estrogenic potential of water and waste water - Part 2: Yeast estrogen screen (Arxula adeninivorans)". Within session 6.08" Risk assessment and management of waterbodies (ground, [...]

1402, 2017

Anakon 2017

February 14th, 2017|Comments Off on Anakon 2017

When?  3rd - 6th of April Where?  University Tübingen, Germany Where can you find us at ANAKON? We will have not only a stand but we will also be present a poster. Visit us at stand A7! In cooperation with QuoData GmbH we will also have a poster entitled "Sample- specific relationship between estrogenic activity and sample dilution" (Umw34) on display within the session "Water and Environmental Analytics".   Tübingen. Photo: Martin Naujocks (2006)

1412, 2016

Endocrine disruption in Antarctic waters

December 14th, 2016|Comments Off on Endocrine disruption in Antarctic waters

  Chemicals that exert endocrine effects in organisms, commonly referred to as endocrine-disrupting compounds (EDCs), have become a growing concern in recent years. Exposure to EDCs is currently regarded as one of the most serious anthropogenic threats to biodiversity and particularly to aquatic ecosystems through breeding disruption and fecundity reduction in a variety of marine species. EDCs are particularly harmful to reproductive and early development phases and the most commonly reported EDCs, namely estrogenic active compounds, have been associated with developmental and reproductive abnormalities in a variety of aquatic wildlife, [...]

512, 2016

Recent published article in the LABO journal November 2016

December 5th, 2016|Comments Off on Recent published article in the LABO journal November 2016

Find our recent released and published specialist article about the topic " water- and wastewater analytics" in the LABO journal . In case of questions or interest feel free to contact us. Your new_diagnoistics team.

2408, 2016

The new_diagnostics Quality Guarantee

August 24th, 2016|Comments Off on The new_diagnostics Quality Guarantee

Accurate measurements and reliable results are essential in the science of food and water. As a result, new_diagnostics undertook a comprehensive validation of its analysis methods for use in the food industry. The study was conducted with several laboratories and the results were published. Furthermore, all components used by new_diagnostics are subjected to a quality inspection before their implementation. Learn more about our quality assurance practices.

204, 2016

ISO certification of the A- YES® – A standardized method for detection of estrogens in water

April 2nd, 2016|Comments Off on ISO certification of the A- YES® – A standardized method for detection of estrogens in water

There are no limits to testing the estrogenic activity of environmental samples because there is no shortage of estrogen-like substances (ex. Bisphenol A) to investigate and no laws regulating their presence in water. This problem will be discussed at the level of the European Union with the hopes of introducing legislation addressing limits for estrogen-like substances in the Water Framework Directive (WFD). Their Environmental Quality Standards define policies for substances which pose a significant danger to the environment or human health. Putting such polices into action requires an efficient and reliable [...]

1408, 2015

Development of a recombinant Arxula adeninivorans cell bioassay for the detection of molecules with progesterone activity in wastewater.

August 14th, 2015|Comments Off on Development of a recombinant Arxula adeninivorans cell bioassay for the detection of molecules with progesterone activity in wastewater.

Alexandre Chamas & Annabel Nieter & Ha Thi Minh Pham & Martin Giersberg & Karina Hettwer & Steffen Uhlig & Kirsten Simon & Keith Baronian & Gotthard Kunze This study describes the development of a bioassay to detect the presence of progesterone and progesterone-like molecules in wastewater samples. The basis of the bioassay is the integration of the human progesterone receptor gene into the yeast Arxula adeninivorans for the constitutive synthesis of the receptor. After incubation, binding of the analyte to the receptor induces the production of a reporter [...]

402, 2015

The determination of pharmaceuticals in wastewater using a recombinant Arxula adeninivorans whole cell biosensor

February 4th, 2015|Comments Off on The determination of pharmaceuticals in wastewater using a recombinant Arxula adeninivorans whole cell biosensor

An Arxula adeninivorans based microbial biosensor has been developed for the determination of pharma- ceuticals and chemicals such as omeprazole, lansoprazole, ?-naphtoflavone and methylcholanthrene within 5 h using biochemical detection and 4 h and 10 min using amperometric detection. The biosen- sor consists of genetically modified A. adeninivorans G1212/YRC102-hAhR-hARNT-phyK (hAhR – human arylhydrocarbon receptor; hARNT – human arylhydrocarbon receptor nuclear translocator; inducible phyK – derived from Klebsiella sp. ASR1) as the biological component and coupled with either a bio- chemical or an amperometric detection method. The combination between hAh receptor [...]

101, 2015

Kinetic Analyses of Data from a Human Serum Albumin Assay Using the liSPR System

January 1st, 2015|Comments Off on Kinetic Analyses of Data from a Human Serum Albumin Assay Using the liSPR System

Anja Henseleit , Carolin Pohl, Hans-Michael Kaltenbach, Karina Hettwer, Kirsten Simon, Steffen Uhlig, Natalie Haustein, Thomas Bley and Elke Boschke  We used the interaction between human serum albumin (HSA) and a high-affinity antibody to evaluate binding affinity measurements by the bench-top liSPR system (capitalis technology GmbH). HSA was immobilized directly onto a carboxylated sensor layer, and the mechanism of interaction between the antibody and HSA was investigated. The bivalence and heterogeneity of the antibody caused a complex binding mechanism. Three different interaction models (1:1 binding, heterogeneous analyte, bivalent analyte) were compared, [...]

Projects

Endocrine disruption in Antarctic waters

December 14th, 2016|Comments Off on Endocrine disruption in Antarctic waters

  Chemicals that exert endocrine effects in organisms, commonly referred to as endocrine-disrupting compounds (EDCs), have become a growing concern in recent years. Exposure to EDCs is currently regarded as one of the most serious anthropogenic threats to biodiversity and particularly to aquatic ecosystems through breeding disruption and fecundity reduction in a variety of marine species. EDCs are particularly harmful to reproductive and early development phases and the most commonly reported EDCs, namely estrogenic active compounds, have been associated with [...]